Medicine

Progressing ASO therapies from progression to implementation

.Contending rate of interests.R.S., M.S., H.G. and A.A.R. are actually planners of the 1M1M campaign. H.G. as well as A.A.R. are actually board of directors participants and also R.S., M.S. and also A.A.R. are participants of the medical advisory committee of N1C. A.A.R. divulges job by LUMC, which has licenses on exon-skipping modern technology, a number of which has actually been certified to BioMarin as well as subsequently sublicensed to Sarepta. As co-inventor of a number of these licenses, A.A.R. was actually entitled to a portion of aristocracies. A.A.R. further reveals serving as impromptu expert for PTC Rehabs, Sarepta Rehabs, Regenxbio, Dyne Rehabs, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco and also Astra Zeneca. Over the last 5 years, A.A.R. additionally did ad hoc consulting for Alpha Anomeric. A.A.R. additionally mentions subscription of the medical boards of advisers of Eisai, Hybridize Therapeutics, Silence Therapeutics, Sarepta Therapeutics, Sapreme and also Mitorx. Previously 5 years, A.A.R. was actually additionally a scientific advisory board participant for ProQR. Pay for A.A.R. u00e2 s consulting as well as recommending tasks is paid for to LUMC. In the past 5 years, LUMC additionally acquired audio speaker honoraria from PTC Rehabs, Alnylam Netherlands, Italfarmaco and also Pfizer and also funding for agreement research coming from Sapreme, Eisai, Galapagos, Synaffix and also Alpha Anomeric. Venture backing is gotten from Sarepta Therapies and also Entrada via unregulated gives. H.G. has nothing to disclose in regard to the topics dealt with in this manuscript. Previously 5 years, he has actually likewise obtained working as a consultant gratuity coming from UCB. M.S. obtained consultancy honoraria coming from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly and also Solaxa over the last 5 years, all unassociated to the here and now manuscript. R.S. possesses nothing to disclose in regard to the subject matters covered within this composition. She has actually obtained sound speaker and/or working as a consultant gratuity or even funding payments coming from Abbvie, Bial, STADA and also Everpharma before 5 years.

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